Best GLP-1 Medications

ClearLiving’s partners provide compounded formulations and do not provide the brand-name medications listed below.

 

Ozempic® (Semaglutide) : Ozempic® is an FDA-approved weekly injection specifically designed to treat type 2 diabetes. Its active ingredient, semaglutide, mimics the GLP-1 hormone naturally produced in the gut. While studies have shown it may be associated with weight loss in individuals with type 2 diabetes, Ozempic® is technically only FDA-approved for diabetes management.

 

Wegovy® (Semaglutide) : Wegovy® utilizes semaglutide but is specifically FDA-approved for chronic weight management. It is indicated for adults with a BMI of 30 or higher, or those with a BMI of 27 who have at least one weight-related medical condition. Wegovy® is administered as a once-weekly injection.

 

Saxenda® (Liraglutide) : Saxenda® is a GLP-1 receptor agonist that uses the active ingredient liraglutide. It is FDA-approved for adults with a BMI of 30+ (or 27+ with comorbidities) and for adolescents aged 12 and older weighing over 132 pounds. Unlike the weekly semaglutide options, Saxenda® requires a daily injection.

 

 

^{†Ozempic® (semaglutide) is a prescription-only subcutaneous injection that has not been approved by the FDA as safe and effective to treat obesity and overweight; however, studies have shown that it may be associated with weight loss in individuals with type 2 diabetes.}

^{††Wegovy® (semaglutide) is a prescription-only subcutaneous injection that helps to reduce excess body weight and maintain weight reduction in adults with obesity and adults with overweight and at least one weight-related condition.}

^{†††Zepbound® (tirzepatide) is a prescription-only subcutaneous injection that, when combined with a reduced-calorie diet and exercise, helps to reduce excess body weight and maintain weight reduction in adults with obesity or overweight and at least one weight-related condition, as well as moderate to severe obstructive sleep apnea in adults with obesity.}

^{††††Generic Liraglutide (liraglutide injection) is a prescription-only subcutaneous injection that, as an adjunct to diet and exercise, helps to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus.}

Prescription weight loss injections should not be confused with over-the-counter “fat-burning” pills or supplements. While many weight loss supplements are loosely regulated and marketed as quick fixes, prescription injections undergo rigorous clinical testing and must be authorized by a healthcare provider. These medications are proven to be  for long-term weight management when used alongside a healthy diet and lifestyle.

Choosing a weight loss medication is a personal decision that should be made in partnership with a healthcare provider. Because these are long-term medical treatments, the “best” option depends on your health profile, lifestyle, and preferences.

When discussing options with your doctor, consider these four key factors:

• Your Health Goals and BMI: Most medications are approved for adults with a BMI of 30+ (obesity) or a BMI of 27+ (overweight) with at least one weight-related condition like high blood pressure or type 2 diabetes.

• Administration Preference: Consider how the medication fits into your routine. Are you comfortable with a weekly self-injection, or would you prefer a daily injection? There are also oral options for those who prefer tablets over needles.

• Side Effect Tolerance: Most GLP-1 medications (injections) cause temporary gastrointestinal side effects like nausea or constipation as your body adjusts. If you have a history of specific issues—such as pancreatitis or certain thyroid conditions—some medications may be ruled out entirely.

• Insurance and Cost: This is often the deciding factor. Coverage for weight loss medications varies wildly between insurance plans. Some telehealth platforms offer compounded versions or help navigate “Prior Authorization” to make branded medications more affordable.